Stopping the Spread Screens

With all the new Spread and Fun & Gun offenses sprouting up out in High School the play that seems to continue to be a tough play to stop and prepare for are the Screens. All kinds i.e. Bubble Screens to the Slots and Flankers, Middle Screens to the RB and Y, and all that apply to the spread. My question is simple, " How do you prepare, other then formation tendency, and how to you stop it other then good tackling and getting off the blocks?
I'm sure I'm not the first to ask but I think I maybe the first to ask out loud.
Coach Hawg