4-3 vs 2 TE and 2 RB?

How do you defend against a 2 x 2 (2 TE and 2 RB) offensive formation if your base 4-3 is a college (Miami 7-3-1-5 vs pro set) or if it is an under/eagle 4-3 (5-1-3-5)? If you bring 8 in the box, what is your favorite way to do it? What coverages do you like to play on running downs? Passing downs - are you still 8 in the box?

Thanks.