Reading 5 Across When Passing Against a 3-3-5?

Coaches, I'm interested in knowing how you attack the 3-3-5 when passing. What we see with this defense is a 3-3 stack in the box, and the defensive backfield has 5 across at 7 yards off the LOS. There are no pre-snap alignments with the 5 across to determine if they are in C3, C2, C1, etc. For example, the Corner could play deep 1/3, he could shuffle forward and funnel to play C2, or he could slide inside and play a loose man technique, but pre-snap you have no idea of knowing which. How do you teach your QBs to read the 5 across defense when passing? How would you execute a 2X2 mirrored Smash combo (#1 hitch, #2 corner/sail) against this look? Thanks.

kd